Open Access System for Information Sharing

Login Library

 

Article
Cited 4 time in webofscience Cited 4 time in scopus
Metadata Downloads

Cardioprotective Effect of the SDF-1 alpha/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts SCIE SCOPUS KCI

Title
Cardioprotective Effect of the SDF-1 alpha/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts
Authors
Kim, Jeong SuJang, YounghoKim, June HongPark, Yong HyunHwang, Sun AeKim, JunLee, Sung-RyulXu, ZhelongBan, ChangillAhn, KyohanChun, Kook Jin
Date Issued
2017-11
Publisher
대한심장학회
Abstract
Background and Objectives: Information about the role of the stromal cell-derived factor1a (SDF-1 alpha)/chemokine receptor type 4 (CXCR4) axis in ischemic postconditioning (IPOC) is currently limited. We hypothesized that the SDF-1 alpha/CXCR4 signaling pathway is directly involved in the cardioprotective effect of IPOC. Methods: Isolated rat hearts were divided into four groups. The control group was subjected to 30-min of regional ischemia and 2-hour of reperfusion (n=12). The IPOC group was induced with 6 cycles of 10-second reperfusion and 10-second global ischemia (n=8) in each cycle. The CXCR4 antagonist, AMD3100, was applied before reperfusion in the IPOC group (AMD+IPOC group, n=11) and control group (AMD group, n=9). Hemodynamic changes with electrocardiography were monitored and infarct size was measured. The SDF-1 alpha, lactate dehydrogenase (LDH) and creatine kinase (CK) concentrations in perfusate were measured. We also analyzed extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation state expression. Results: IPOC significantly reduced infarct size, but AMD3100 attenuated the infarct reducing effect of IPOC. IPOC significantly decreased LDH and CK, but these effects were reversed by AMD3100. ERK1/2 and Akt phosphorylation increased with IPOC and these effects were blocked by AMD3100. Conclusion: Based on the results of this study, SDF-1 alpha/CXCR4 signaling may be involved in IPOC cardioprotection and this signaling pathway couples to the ERK1/2 and Akt pathways.
URI
https://oasis.postech.ac.kr/handle/2014.oak/50698
DOI
10.4070/kcj.2016.0353
ISSN
1738-5520
Article Type
Article
Citation
Korean Circulation Journal, vol. 47, no. 6, page. 949 - 959, 2017-11
Files in This Item:

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

반창일BAN, CHANGILL
Dept of Chemistry
Read more

Views & Downloads

Browse