DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Su | - |
dc.contributor.author | Jang, Youngho | - |
dc.contributor.author | Kim, June Hong | - |
dc.contributor.author | Park, Yong Hyun | - |
dc.contributor.author | Hwang, Sun Ae | - |
dc.contributor.author | Kim, Jun | - |
dc.contributor.author | Lee, Sung-Ryul | - |
dc.contributor.author | Xu, Zhelong | - |
dc.contributor.author | Ban, Changill | - |
dc.contributor.author | Ahn, Kyohan | - |
dc.contributor.author | Chun, Kook Jin | - |
dc.date.accessioned | 2018-06-15T05:39:07Z | - |
dc.date.available | 2018-06-15T05:39:07Z | - |
dc.date.created | 2018-02-05 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/50698 | - |
dc.description.abstract | Background and Objectives: Information about the role of the stromal cell-derived factor1a (SDF-1 alpha)/chemokine receptor type 4 (CXCR4) axis in ischemic postconditioning (IPOC) is currently limited. We hypothesized that the SDF-1 alpha/CXCR4 signaling pathway is directly involved in the cardioprotective effect of IPOC. Methods: Isolated rat hearts were divided into four groups. The control group was subjected to 30-min of regional ischemia and 2-hour of reperfusion (n=12). The IPOC group was induced with 6 cycles of 10-second reperfusion and 10-second global ischemia (n=8) in each cycle. The CXCR4 antagonist, AMD3100, was applied before reperfusion in the IPOC group (AMD+IPOC group, n=11) and control group (AMD group, n=9). Hemodynamic changes with electrocardiography were monitored and infarct size was measured. The SDF-1 alpha, lactate dehydrogenase (LDH) and creatine kinase (CK) concentrations in perfusate were measured. We also analyzed extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation state expression. Results: IPOC significantly reduced infarct size, but AMD3100 attenuated the infarct reducing effect of IPOC. IPOC significantly decreased LDH and CK, but these effects were reversed by AMD3100. ERK1/2 and Akt phosphorylation increased with IPOC and these effects were blocked by AMD3100. Conclusion: Based on the results of this study, SDF-1 alpha/CXCR4 signaling may be involved in IPOC cardioprotection and this signaling pathway couples to the ERK1/2 and Akt pathways. | - |
dc.language | English | - |
dc.publisher | 대한심장학회 | - |
dc.relation.isPartOf | Korean Circulation Journal | - |
dc.title | Cardioprotective Effect of the SDF-1 alpha/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts | - |
dc.title.alternative | Cardioprotective Effect of the SDF-1α/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts | - |
dc.type | Article | - |
dc.identifier.doi | 10.4070/kcj.2016.0353 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Korean Circulation Journal, v.47, no.6, pp.949 - 959 | - |
dc.identifier.kciid | ART002288318 | - |
dc.identifier.wosid | 000418292300017 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 959 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 949 | - |
dc.citation.title | Korean Circulation Journal | - |
dc.citation.volume | 47 | - |
dc.contributor.affiliatedAuthor | Ban, Changill | - |
dc.contributor.affiliatedAuthor | Ahn, Kyohan | - |
dc.identifier.scopusid | 2-s2.0-85039872797 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SALVAGE KINASE PATHWAY | - |
dc.subject.keywordPlus | REPERFUSION INJURY | - |
dc.subject.keywordPlus | INFARCT SIZE | - |
dc.subject.keywordPlus | ISCHEMIA/REPERFUSION INJURY | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | CELL RECRUITMENT | - |
dc.subject.keywordPlus | RABBIT HEARTS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | CXCR4 | - |
dc.subject.keywordAuthor | Reperfusion injury | - |
dc.subject.keywordAuthor | Ischemic postconditioning | - |
dc.subject.keywordAuthor | Stromal cell-derived factor-1 alpha | - |
dc.subject.keywordAuthor | CXCR4 receptors | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
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