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Crystal structure of the human GINS complex SCIE SCOPUS

Title
Crystal structure of the human GINS complex
Authors
Choi, JMLim, HSKim, JJSong, OKCho, YJ
Date Issued
2007-06-01
Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Abstract
The GINS complex mediates the assembly of the MCM2-7 (minichromosome maintenance) complex with proteins in a replisome progression complex. The eukaryotic GINS complex is composed of Sld5, Psf1, Psf2, and Psf3, which must be assembled for cell proliferation. We determined the crystal structure of the human GINS complex: GINS forms an elliptical shape with a small central channel. The structures of Sld5 and Psf2 resemble those of Psf1 and Psf3, respectively. In addition, the N-terminal and C-terminal domains of Sld5/ Psf1 are permuted in Psf2/ Psf3, which suggests that the four proteins have evolved from a common ancestor. Using a structure- based mutational analysis, we identified the functionally critical surface regions of the GINS complex.
URI
https://oasis.postech.ac.kr/handle/2014.oak/29520
DOI
10.1101/GAD.1548107
ISSN
0890-9369
Article Type
Article
Citation
GENES & DEVELOPMENT, vol. 21, no. 11, page. 1316 - 1321, 2007-06-01
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조윤제CHO, YUNJE
Dept of Life Sciences
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