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C5-Modified nucleosides exhibiting anticancer activity SCIE SCOPUS
- Title
- C5-Modified nucleosides exhibiting anticancer activity
- Date Issued
- 2009-08-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-2'deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-2'-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-2'-deoxyuridine provided triazole derivatives. (C) 2009 Elsevier Ltd. All rights reserved.
- Keywords
- Anticancer; Nucleoside; Triazole; Isoxazole; Cycloaddition; CANCER; IDENTIFICATION; CYTOTOXICITY; CLOFARABINE; ISOXAZOLE; ANALOGS; DESIGN; CELLS
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 16, page. 4688 - 4691, 2009-08-15
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Related Researcher
- 김병현KIM, BYEANG HYEAN
- Div of Advanced Materials Science