Reduction-Sensitive, Robust Vesicles with a Non-covalently Modifiable Surface as a Multifunctional Drug-Delivery Platform
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SCOPUS
- Title
- Reduction-Sensitive, Robust Vesicles with a Non-covalently Modifiable Surface as a Multifunctional Drug-Delivery Platform
- Authors
- Park, KM; Lee, DW; Sarkar, B; Jung, H; Kim, J; Ko, YH; Lee, KE; Jeon, H; Kim, K
- Date Issued
- 2010-07-05
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- The design and synthesis of a novel reduction-sensitive, robust, and biocompatible vesicle (SSCB[6]VC) are reported, which is self-assembled from an amphiphilic cucurbit[6]uril (CB[6]) derivative that contains disulfide bonds between hexaethylene glycol units and a CB[6] core. The remarkable features of SSCB[6]VC include: 1) facile, non-destructive, non-covalent, and modular surface modification using exceptionally strong host guest chemistry; 2) high structural stability; 3) facile internalization into targeted cells by receptor-mediated endocytosis and 4) efficient triggered release of entrapped drugs in a reducing environment such as cytoplasm. Furthermore, a significantly increased cytotoxicity of the anticancer drug doxorubicin to cancer cells is demonstrated using doxorubicin-loaded SSCB[6]VC, the surface of which is decorated with functional moieties such as a folate spermidine conjugate and fluorescein isothiocyanate spermidine conjugate as targeting ligand and fluorescence imaging probe, respectively. SSCB[6]VC with such unique features can be used as a highly versatile multifunctional platform for targeted drug delivery, which may find useful applications in cancer therapy. This novel strategy based on supramolecular chemistry and the unique properties of CB[6] can be extended to design smart multifunctional materials for biomedical applications including gene delivery.
- Keywords
- cucurbiturils; cytotoxicity; drug delivery; host-guest systems; vesicles; GENE DELIVERY; INTRACELLULAR DELIVERY; CUCURBITURIL HOMOLOGS; DIBLOCK COPOLYMERS; LIPOSOMES; NANOPARTICLES; CANCER; COMPLEXATION; DOXORUBICIN; DERIVATIVES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25820
- DOI
- 10.1002/SMLL.201000293
- ISSN
- 1613-6810
- Article Type
- Article
- Citation
- SMALL, vol. 6, no. 13, page. 1430 - 1441, 2010-07-05
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- There are no files associated with this item.
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