DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, KM | - |
dc.contributor.author | Lee, DW | - |
dc.contributor.author | Sarkar, B | - |
dc.contributor.author | Jung, H | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Ko, YH | - |
dc.contributor.author | Lee, KE | - |
dc.contributor.author | Jeon, H | - |
dc.contributor.author | Kim, K | - |
dc.date.accessioned | 2016-04-01T02:49:15Z | - |
dc.date.available | 2016-04-01T02:49:15Z | - |
dc.date.created | 2010-09-07 | - |
dc.date.issued | 2010-07-05 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.other | 2010-OAK-0000021512 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25820 | - |
dc.description.abstract | The design and synthesis of a novel reduction-sensitive, robust, and biocompatible vesicle (SSCB[6]VC) are reported, which is self-assembled from an amphiphilic cucurbit[6]uril (CB[6]) derivative that contains disulfide bonds between hexaethylene glycol units and a CB[6] core. The remarkable features of SSCB[6]VC include: 1) facile, non-destructive, non-covalent, and modular surface modification using exceptionally strong host guest chemistry; 2) high structural stability; 3) facile internalization into targeted cells by receptor-mediated endocytosis and 4) efficient triggered release of entrapped drugs in a reducing environment such as cytoplasm. Furthermore, a significantly increased cytotoxicity of the anticancer drug doxorubicin to cancer cells is demonstrated using doxorubicin-loaded SSCB[6]VC, the surface of which is decorated with functional moieties such as a folate spermidine conjugate and fluorescein isothiocyanate spermidine conjugate as targeting ligand and fluorescence imaging probe, respectively. SSCB[6]VC with such unique features can be used as a highly versatile multifunctional platform for targeted drug delivery, which may find useful applications in cancer therapy. This novel strategy based on supramolecular chemistry and the unique properties of CB[6] can be extended to design smart multifunctional materials for biomedical applications including gene delivery. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | SMALL | - |
dc.subject | cucurbiturils | - |
dc.subject | cytotoxicity | - |
dc.subject | drug delivery | - |
dc.subject | host-guest systems | - |
dc.subject | vesicles | - |
dc.subject | GENE DELIVERY | - |
dc.subject | INTRACELLULAR DELIVERY | - |
dc.subject | CUCURBITURIL HOMOLOGS | - |
dc.subject | DIBLOCK COPOLYMERS | - |
dc.subject | LIPOSOMES | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CANCER | - |
dc.subject | COMPLEXATION | - |
dc.subject | DOXORUBICIN | - |
dc.subject | DERIVATIVES | - |
dc.title | Reduction-Sensitive, Robust Vesicles with a Non-covalently Modifiable Surface as a Multifunctional Drug-Delivery Platform | - |
dc.type | Article | - |
dc.contributor.college | 첨단재료과학부 | - |
dc.identifier.doi | 10.1002/SMLL.201000293 | - |
dc.author.google | Park, KM | - |
dc.author.google | Lee, DW | - |
dc.author.google | Sarkar, B | - |
dc.author.google | Jung, H | - |
dc.author.google | Kim, J | - |
dc.author.google | Ko, YH | - |
dc.author.google | Lee, KE | - |
dc.author.google | Jeon, H | - |
dc.author.google | Kim, K | - |
dc.relation.volume | 6 | - |
dc.relation.issue | 13 | - |
dc.relation.startpage | 1430 | - |
dc.relation.lastpage | 1441 | - |
dc.contributor.id | 10104366 | - |
dc.relation.journal | SMALL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | SMALL, v.6, no.13, pp.1430 - 1441 | - |
dc.identifier.wosid | 000280219500011 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1441 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 1430 | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Kim, K | - |
dc.identifier.scopusid | 2-s2.0-77954304412 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 77 | - |
dc.description.scptc | 75 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | INTRACELLULAR DELIVERY | - |
dc.subject.keywordPlus | CUCURBITURIL HOMOLOGS | - |
dc.subject.keywordPlus | DIBLOCK COPOLYMERS | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COMPLEXATION | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordAuthor | cucurbiturils | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | host-guest systems | - |
dc.subject.keywordAuthor | vesicles | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
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