The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis
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SCOPUS
- Title
- The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis
- Authors
- Lee, YN; Lee, HY; Kim, JS; Park, C; Choi, YH; Lee, TG; Ryu, SH; Kwak, JY; Bae, YS
- Date Issued
- 2005-05-26
- Publisher
- ELSEVIER IRELAND LTD
- Abstract
- We investigated the effect of the novel phospholipase C activator, m-3M3FBS, on the apoptosis of leukemic cells. m-3M3FBS inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3M3FBS induced the apoptosis of U937 cells, which was accompanied by chromatin condensation and DNA fragmentation. Moreover, m-3M3FBS-induced apoptosis appeared to involve the down-regulation of anti-apoptotic Bcl-2, the up-regulation of proapoptotic Bax, the release of cytochrome c, and caspase activation. m-3M3FBS-induced apoptosis of U937 cells was also partly inhibited by BAPTA-AM and EGTA, indicating the involvement of intracellular calcium signaling on the apoptosis in U937 cells. The results of our study suggest that m-3M3FBS can be developed as a novel anti-leukemic agent. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
- Keywords
- m-3M3FBS; apoptosis; U937; Ca2+; Bcl-2; caspase; OXIDATIVE STRESS; INTRACELLULAR CA2+; HYDROGEN-PEROXIDE; N-ACETYLCYSTEINE; CYTOCHROME-C; U937 CELLS; CALCIUM; DEATH; IDENTIFICATION; SUPEROXIDE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/24583
- DOI
- 10.1016/j.canlet.2004.09.017
- ISSN
- 0304-3835
- Article Type
- Article
- Citation
- CANCER LETTERS, vol. 222, no. 2, page. 227 - 235, 2005-05-26
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