DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, YN | - |
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Park, C | - |
dc.contributor.author | Choi, YH | - |
dc.contributor.author | Lee, TG | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Kwak, JY | - |
dc.contributor.author | Bae, YS | - |
dc.date.accessioned | 2016-04-01T02:10:28Z | - |
dc.date.available | 2016-04-01T02:10:28Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2005-05-26 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 2005-OAK-0000005137 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24583 | - |
dc.description.abstract | We investigated the effect of the novel phospholipase C activator, m-3M3FBS, on the apoptosis of leukemic cells. m-3M3FBS inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3M3FBS induced the apoptosis of U937 cells, which was accompanied by chromatin condensation and DNA fragmentation. Moreover, m-3M3FBS-induced apoptosis appeared to involve the down-regulation of anti-apoptotic Bcl-2, the up-regulation of proapoptotic Bax, the release of cytochrome c, and caspase activation. m-3M3FBS-induced apoptosis of U937 cells was also partly inhibited by BAPTA-AM and EGTA, indicating the involvement of intracellular calcium signaling on the apoptosis in U937 cells. The results of our study suggest that m-3M3FBS can be developed as a novel anti-leukemic agent. (c) 2004 Elsevier Ireland Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.subject | m-3M3FBS | - |
dc.subject | apoptosis | - |
dc.subject | U937 | - |
dc.subject | Ca2+ | - |
dc.subject | Bcl-2 | - |
dc.subject | caspase | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | INTRACELLULAR CA2+ | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | N-ACETYLCYSTEINE | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | U937 CELLS | - |
dc.subject | CALCIUM | - |
dc.subject | DEATH | - |
dc.subject | IDENTIFICATION | - |
dc.subject | SUPEROXIDE | - |
dc.title | The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.canlet.2004.09.017 | - |
dc.author.google | Lee, YN | - |
dc.author.google | Lee, HY | - |
dc.author.google | Kim, JS | - |
dc.author.google | Park, C | - |
dc.author.google | Choi, YH | - |
dc.author.google | Lee, TG | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Kwak, JY | - |
dc.author.google | Bae, YS | - |
dc.relation.volume | 222 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 227 | - |
dc.relation.lastpage | 235 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | CANCER LETTERS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.222, no.2, pp.227 - 235 | - |
dc.identifier.wosid | 000229351800012 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 235 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 227 | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 222 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-18044381911 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INTRACELLULAR CA2+ | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | N-ACETYLCYSTEINE | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | U937 CELLS | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | SUPEROXIDE | - |
dc.subject.keywordAuthor | m-3M3FBS | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | U937 | - |
dc.subject.keywordAuthor | Ca2+ | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.subject.keywordAuthor | caspase | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
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