Osteoprotegerin ligand: a regulator of immune responses and bone physiology
SCIE
SCOPUS
- Title
- Osteoprotegerin ligand: a regulator of immune responses and bone physiology
- Authors
- Kong, YY; Boyle, WJ; Penninger, JM
- Date Issued
- 2000-10
- Publisher
- ELSEVIER SCI LTD
- Abstract
- The TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts. Intriguingly, OPGL also regulates T cell-dendritic cell communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune system and in bone metabolism.
- Keywords
- TUMOR-NECROSIS-FACTOR; PERIPHERAL LYMPHOID ORGANS; OSTEOCLASTOGENESIS-INHIBITORY FACTOR; LYMPHOTOXIN BETA-RECEPTOR; APOPTOSIS-INDUCING LIGAND; TNF FAMILY MEMBER; T-CELLS; RHEUMATOID-ARTHRITIS; DENDRITIC CELLS; DEFICIENT MICE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19829
- DOI
- 10.1016/S0167-5699(00)01718-7
- ISSN
- 0167-5699
- Article Type
- Article
- Citation
- IMMUNOLOGY TODAY, vol. 21, no. 10, page. 495 - 502, 2000-10
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