Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection
- Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection
- Chang, J; Choi, SY; Jin, HT; Sung, YC; Braciale, TJ
- Date Issued
- AMER ASSOC IMMUNOLOGISTS
- Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. Studies of mice suggest that RSV suppresses the effector activity of CD8 T cells and the development of pulmonary CD8 T cell memory, in which the impaired effector activity could be recovered by in vitro IL-2 treatment. To investigate the effect of in vivo IL-2 expression on RSV immunity, mice were infected with RSV followed by administration of replication-defective adenovirus expressing IL-2. The effector activity of RSV M2-specific CD8 T cells and the development of CD8 T cell memory in the lung was significantly increased by IL-2 expression. Furthermore, the Ab responses against RSV were augmented by IL-2. Interestingly, weight loss and illness caused by RSV challenge were substantially reduced by IL-2 priming, suggesting that the pathogenesis of RSV-related disease could be prevented by IL-2-mediated enhancement of beneficial immune responses. Thus, our results show that IL-2 has potential to be used as a vaccine adjuvant against RSV infection.
- LYMPHOCYTES; ANTIGEN; INTERLEUKIN-2; MICE; EOSINOPHILIA; IMMUNITY; DISEASE; PERSIST; MAINTENANCE; ACTIVATION
- Article Type
- JOURNAL OF IMMUNOLOGY, vol. 172, no. 1, page. 503 - 508, 2004-01-01
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