DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, J | - |
dc.contributor.author | Choi, SY | - |
dc.contributor.author | Jin, HT | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Braciale, TJ | - |
dc.date.accessioned | 2016-03-31T12:40:55Z | - |
dc.date.available | 2016-03-31T12:40:55Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2004-01-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2004-OAK-0000003891 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18193 | - |
dc.description.abstract | Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. Studies of mice suggest that RSV suppresses the effector activity of CD8 T cells and the development of pulmonary CD8 T cell memory, in which the impaired effector activity could be recovered by in vitro IL-2 treatment. To investigate the effect of in vivo IL-2 expression on RSV immunity, mice were infected with RSV followed by administration of replication-defective adenovirus expressing IL-2. The effector activity of RSV M2-specific CD8 T cells and the development of CD8 T cell memory in the lung was significantly increased by IL-2 expression. Furthermore, the Ab responses against RSV were augmented by IL-2. Interestingly, weight loss and illness caused by RSV challenge were substantially reduced by IL-2 priming, suggesting that the pathogenesis of RSV-related disease could be prevented by IL-2-mediated enhancement of beneficial immune responses. Thus, our results show that IL-2 has potential to be used as a vaccine adjuvant against RSV infection. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | ANTIGEN | - |
dc.subject | INTERLEUKIN-2 | - |
dc.subject | MICE | - |
dc.subject | EOSINOPHILIA | - |
dc.subject | IMMUNITY | - |
dc.subject | DISEASE | - |
dc.subject | PERSIST | - |
dc.subject | MAINTENANCE | - |
dc.subject | ACTIVATION | - |
dc.title | Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.172.1.503 | - |
dc.author.google | Chang, J | - |
dc.author.google | Choi, SY | - |
dc.author.google | Jin, HT | - |
dc.author.google | Sung, YC | - |
dc.author.google | Braciale, TJ | - |
dc.relation.volume | 172 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 503 | - |
dc.relation.lastpage | 508 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.172, no.1, pp.503 - 508 | - |
dc.identifier.wosid | 000187427700062 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 508 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 503 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 172 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0347364682 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 26 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PERSIST | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | INTERLEUKIN-2 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EOSINOPHILIA | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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