Microfabricated platforms to modulate and monitor T cell synapse assembly
SCIE
SCOPUS
- Title
- Microfabricated platforms to modulate and monitor T cell synapse assembly
- Authors
- Hong-Ryul Jung; Jong-Cheol Choi; Wonhwa Cho; Doh, J
- Date Issued
- 2013-01
- Publisher
- Wiley Periodicals, Inc.
- Abstract
- Immunological synapse (IS) is a complex supramolecular structure formed at the interface between T cells and antigen presenting cells (APCs) during T cell antigen recognition. Microfabricated platforms have made great contributions to our understanding of the assembly dynamics and functional roles of the T cell synapses over the last decade. Here, we review three different types of microfabricated platforms developed to modulate andmonitor the T cell synapse assembly. Firstly, multi-protein micropatterned surfaces presenting key ligands for T cell activation that can modulate the spatial distribution of receptors/signaling molecules in T cell synapses are described. Secondly, micropatterned supported bilayers that can modulate the dynamics of T cell receptor (TCR) microclusters are introduced. Lastly, T-APC pair arrays that allow for improved fluorescence live cell imaging are discussed. (C) 2012 Wiley Periodicals, Inc.
- Keywords
- SUPRAMOLECULAR ACTIVATION CLUSTER; KINASE-C-THETA; IMMUNOLOGICAL SYNAPSE; ANTIGEN RECEPTOR; SIGNALING MOLECULES; LIGAND RECOGNITION; MICROCLUSTERS; SURFACES; BILAYERS; LYMPHOCYTES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16156
- DOI
- 10.1002/WNAN.1182
- ISSN
- 1939-5116
- Article Type
- Article
- Citation
- Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 5, no. 1, page. 67 - 74, 2013-01
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