IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
SCIE
SCOPUS
- Title
- IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
- Authors
- Letourneau, S; van Leeuwen, EMM; Krieg, C; Martin, C; Pantaleo, G; Sprent, J; Surh, CD; Boyman, O
- Date Issued
- 2010-02-02
- Publisher
- National Academy of Sciences
- Abstract
- IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.
- Keywords
- CD25; cytokine; cytokine/mAb complexes; T cell homeostasis; Fc receptor; REGULATORY T-CELLS; IN-VIVO; IMMUNE-COMPLEXES; CUTTING EDGE; AUTOIMMUNE-DISEASE; HEPARAN-SULFATE; DEFICIENT MICE; FUSION PROTEIN; BETA-CHAIN; INTERLEUKIN-2
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14765
- DOI
- 10.1073/PNAS.0909384107
- ISSN
- 0027-8424
- Article Type
- Article
- Citation
- National Academy of Sciences. Proceedings, vol. 107, no. 5, page. 1271 - 1276, 2010-02-02
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