DC Field | Value | Language |
---|---|---|
dc.contributor.author | Letourneau, S | - |
dc.contributor.author | van Leeuwen, EMM | - |
dc.contributor.author | Krieg, C | - |
dc.contributor.author | Martin, C | - |
dc.contributor.author | Pantaleo, G | - |
dc.contributor.author | Sprent, J | - |
dc.contributor.author | Surh, CD | - |
dc.contributor.author | Boyman, O | - |
dc.date.accessioned | 2016-03-31T08:11:35Z | - |
dc.date.available | 2016-03-31T08:11:35Z | - |
dc.date.created | 2014-03-07 | - |
dc.date.issued | 2010-02-02 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 2010-OAK-0000029348 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14765 | - |
dc.description.abstract | IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | National Academy of Sciences. Proceedings | - |
dc.subject | CD25 | - |
dc.subject | cytokine | - |
dc.subject | cytokine/mAb complexes | - |
dc.subject | T cell homeostasis | - |
dc.subject | Fc receptor | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | IN-VIVO | - |
dc.subject | IMMUNE-COMPLEXES | - |
dc.subject | CUTTING EDGE | - |
dc.subject | AUTOIMMUNE-DISEASE | - |
dc.subject | HEPARAN-SULFATE | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | FUSION PROTEIN | - |
dc.subject | BETA-CHAIN | - |
dc.subject | INTERLEUKIN-2 | - |
dc.title | IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1073/PNAS.0909384107 | - |
dc.author.google | Letourneau, S | - |
dc.author.google | van Leeuwen, EMM | - |
dc.author.google | Krieg, C | - |
dc.author.google | Martin, C | - |
dc.author.google | Pantaleo, G | - |
dc.author.google | Sprent, J | - |
dc.author.google | Surh, CD | - |
dc.author.google | Boyman, O | - |
dc.relation.volume | 107 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 1271 | - |
dc.relation.lastpage | 1276 | - |
dc.contributor.id | 10201353 | - |
dc.relation.journal | National Academy of Sciences. Proceedings | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | National Academy of Sciences. Proceedings, v.107, no.5, pp.1271 - 1276 | - |
dc.identifier.wosid | 000274296300067 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1276 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1271 | - |
dc.citation.title | National Academy of Sciences. Proceedings | - |
dc.citation.volume | 107 | - |
dc.contributor.affiliatedAuthor | Surh, CD | - |
dc.identifier.scopusid | 2-s2.0-76649145452 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 92 | - |
dc.description.scptc | 79 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | IMMUNE-COMPLEXES | - |
dc.subject.keywordPlus | HEPARAN-SULFATE | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | FUSION PROTEIN | - |
dc.subject.keywordPlus | BETA-CHAIN | - |
dc.subject.keywordPlus | INTERLEUKIN-2 | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordAuthor | CD25 | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | cytokine/mAb complexes | - |
dc.subject.keywordAuthor | T cell homeostasis | - |
dc.subject.keywordAuthor | Fc receptor | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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