Anodic aluminium oxide membranes for immunoisolation with sufficient oxygen supply for pancreatic islets
SCIE
SCOPUS
- Title
- Anodic aluminium oxide membranes for immunoisolation with sufficient oxygen supply for pancreatic islets
- Authors
- Siwoo Cho; Lee, S; Jeong, SH; Yeongae Kim; Kim, SC; Hwang, W; Park, J
- Date Issued
- 2013-02
- Publisher
- RSC
- Abstract
- Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O-2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report an encapsulation method that uses an anodic aluminum oxide membrane formed by polyethylene oxide self-assembly to obtain nanochannels with both high selectivity in excluding immune molecules and high permeability of nutrients such as glucose, insulin, and O-2. The extracorporeal encapsulation system composed of these membranes allows O-2 flux to meet the O-2 demand of pancreatic islets of Langerhans and provides excellent in vitro viability and functionality of islets.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14541
- DOI
- 10.1039/C3IB20226G
- ISSN
- 1757-9694
- Article Type
- Article
- Citation
- Integrative Biology, vol. 5, no. 5, page. 828 - 834, 2013-02
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