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Cited 118 time in webofscience Cited 134 time in scopus
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Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

Title
Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients
Authors
Kim, TJJin, HTHur, SYYang, HGSeo, YBHong, SRLee, CWKim, SWoo, JWPark, KSHwang, YYPark, JLee, IHLim, KTLee, KHJeong, MSSURH, CHARLES DSuh, YSPark, JSSung, YC
POSTECH Authors
SURH, CHARLES DSung, YC
Date Issued
2014-10
Publisher
NATURE PUBLISHING GROUP
Abstract
Here, we demonstrate that electroporation-enhanced immunization with a rationally designed HPV DNA vaccine (GX-188E), preferentially targeting HPV antigens to dendritic cells, elicits a significant E6/E7-specific IFN-gamma-producing T-cell response in all nine cervical intraepithelial neoplasia 3 (CIN3) patients. Importantly, eight out of nine patients exhibit an enhanced polyfunctional HPV-specific CD8 T-cell response as shown by an increase in cytolytic activity, proliferative capacity and secretion of effector molecules. Notably, seven out of nine patients display complete regression of their lesions and viral clearance within 36 weeks of follow up. GX-188E administration does not elicit serious vaccine-associated adverse events at all administered doses. These findings indicate that the magnitude of systemic polyfunctional CD8 T-cell response is the main contributing factor for histological, cytological and virological responses, providing valuable insights into the design of therapeutic vaccines for effectively treating persistent infections and cancers in humans.
URI
https://oasis.postech.ac.kr/handle/2014.oak/13475
DOI
10.1038/NCOMMS6317
ISSN
2041-1723
Article Type
Article
Citation
NATURE COMMUNICATIONS, vol. 5, 2014-10
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성영철SUNG, YOUNG CHUL
Dept of Life Sciences
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