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Cited 118 time in webofscience Cited 134 time in scopus
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dc.contributor.authorKim, TJko
dc.contributor.authorJin, HTko
dc.contributor.authorHur, SYko
dc.contributor.authorYang, HGko
dc.contributor.authorSeo, YBko
dc.contributor.authorHong, SRko
dc.contributor.authorLee, CWko
dc.contributor.authorKim, Sko
dc.contributor.authorWoo, JWko
dc.contributor.authorPark, KSko
dc.contributor.authorHwang, YYko
dc.contributor.authorPark, Jko
dc.contributor.authorLee, IHko
dc.contributor.authorLim, KTko
dc.contributor.authorLee, KHko
dc.contributor.authorJeong, MSko
dc.contributor.authorSURH, CHARLES Dko
dc.contributor.authorSuh, YSko
dc.contributor.authorPark, JSko
dc.contributor.authorSung, YCko
dc.date.available2016-01-08T14:52:33Z-
dc.date.created2015-02-17-
dc.date.issued2014-10-
dc.identifier.citationNATURE COMMUNICATIONS, v.5-
dc.identifier.issn2041-1723-
dc.identifier.other2014-OAK-0000031223-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/13475-
dc.description.abstractHere, we demonstrate that electroporation-enhanced immunization with a rationally designed HPV DNA vaccine (GX-188E), preferentially targeting HPV antigens to dendritic cells, elicits a significant E6/E7-specific IFN-gamma-producing T-cell response in all nine cervical intraepithelial neoplasia 3 (CIN3) patients. Importantly, eight out of nine patients exhibit an enhanced polyfunctional HPV-specific CD8 T-cell response as shown by an increase in cytolytic activity, proliferative capacity and secretion of effector molecules. Notably, seven out of nine patients display complete regression of their lesions and viral clearance within 36 weeks of follow up. GX-188E administration does not elicit serious vaccine-associated adverse events at all administered doses. These findings indicate that the magnitude of systemic polyfunctional CD8 T-cell response is the main contributing factor for histological, cytological and virological responses, providing valuable insights into the design of therapeutic vaccines for effectively treating persistent infections and cancers in humans.-
dc.description.statementofresponsibilityopen-
dc.format.extentpdf-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleClearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients-
dc.typeArticle-
dc.contributor.college융합생명공학부-
dc.identifier.doi10.1038/NCOMMS6317-
dc.author.googleKim, TJ-
dc.author.googleJin, HT-
dc.author.googleHur, SY-
dc.author.googleYang, HG-
dc.author.googleSeo, YB-
dc.author.googleHong, SR-
dc.author.googleLee, CW-
dc.author.googleKim, S-
dc.author.googleWoo, JW-
dc.author.googlePark, KS-
dc.author.googleHwang, YY-
dc.author.googlePark, J-
dc.author.googleLee, IH-
dc.author.googleLim, KT-
dc.author.googleLee, KH-
dc.author.googleJeong, MS-
dc.author.googleSurh, CD-
dc.author.googleSuh, YS-
dc.author.googlePark, JS-
dc.author.googleSung, YC-
dc.relation.volume5-
dc.contributor.id10053752-
dc.publisher.locationUK-
dc.relation.journalNATURE COMMUNICATIONS-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.contributor.localauthorSURH, CHARLES D-
dc.contributor.localauthorSung, YC-
dc.contributor.nonIdAuthorKim, TJ-
dc.contributor.nonIdAuthorJin, HT-
dc.contributor.nonIdAuthorHur, SY-
dc.contributor.nonIdAuthorYang, HG-
dc.contributor.nonIdAuthorSeo, YB-
dc.contributor.nonIdAuthorHong, SR-
dc.contributor.nonIdAuthorLee, CW-
dc.contributor.nonIdAuthorKim, S-
dc.contributor.nonIdAuthorWoo, JW-
dc.contributor.nonIdAuthorPark, KS-
dc.contributor.nonIdAuthorHwang, YY-
dc.contributor.nonIdAuthorPark, J-
dc.contributor.nonIdAuthorLee, IH-
dc.contributor.nonIdAuthorLim, KT-
dc.contributor.nonIdAuthorLee, KH-
dc.contributor.nonIdAuthorJeong, MS-
dc.contributor.nonIdAuthorSuh, YS-
dc.contributor.nonIdAuthorPark, JS-
dc.identifier.wosid000344061800003-
dc.date.tcdate2019-01-01-
dc.citation.titleNATURE COMMUNICATIONS-
dc.citation.volume5-
dc.identifier.localId0000031223-
dc.identifier.localId0000031223-
dc.identifier.localId0000032024-
dc.identifier.scopusid2-s2.0-84921357729-
dc.description.journalClass1-
dc.description.wostc57-
dc.description.scptc61*
dc.date.scptcdate2018-10-274*

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성영철SUNG, YOUNG CHUL
Dept of Life Sciences
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