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Cited 24 time in webofscience Cited 27 time in scopus
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Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells SCIE SCOPUS

Title
Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells
Authors
Tae-Jin KimMiju KimHye Mi KimSeon Ah LimEun-Ok KimKwanghee KimKwang Hoon SongJiyoung KimVinay KumarCassian YeeDoh, JKyung-Mi Lee
Date Issued
2014-12-05
Publisher
SCIENTIFIC REPORTS
Abstract
While stationary organ cells are in continuous contact with neighboring cells, immune cells circulate throughout the body without an apparent requirement for cell-cell contact to persist in vivo. This study challenges current convention by demonstrating, both in vitro and in vivo, that innate immune NK cells can engage in homotypic NK-to-NK cell interactions for optimal survival, activation, and proliferation. Using a specialized cell-laden microwell approach, we discover that NK cells experiencing constant NK-to-NK contact exhibit a synergistic increase in activation status, cell proliferation, and anti-tumor function in response to IL-2 or IL-15. This effect is dependent on 2B4/CD48 ligation and an active cytoskeleton, resulting in amplification of IL-2 receptor signaling, enhanced CD122/CD132 colocalization, CD25 upregulation, and Stat3 activation. Conversely, 'orphan' NK cells demonstrate no such synergy and fail to persist. Therefore, our data uncover the existence of homotypic cell-to-cell communication among mobile innate lymphocytes, which promotes functional synergy within the cytokine-rich microenvironment.
Keywords
NATURAL-KILLER-CELLS; FOREIGN ANTIGEN; DENDRITIC CELLS; 2B4 CD244; ACTIVATION; RECEPTOR; CYTOTOXICITY; INTERLEUKIN-2; RECOGNITION; SENSITIVITY
URI
https://oasis.postech.ac.kr/handle/2014.oak/13079
DOI
10.1038/SREP07157
ISSN
2045-2322
Article Type
Article
Citation
SCIENTIFIC REPORTS, vol. 4, page. 7157, 2014-12-05
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도준상DOH, JUN SANG
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