DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tae-Jin Kim | - |
dc.contributor.author | Miju Kim | - |
dc.contributor.author | Hye Mi Kim | - |
dc.contributor.author | Seon Ah Lim | - |
dc.contributor.author | Eun-Ok Kim | - |
dc.contributor.author | Kwanghee Kim | - |
dc.contributor.author | Kwang Hoon Song | - |
dc.contributor.author | Jiyoung Kim | - |
dc.contributor.author | Vinay Kumar | - |
dc.contributor.author | Cassian Yee | - |
dc.contributor.author | Doh, J | - |
dc.contributor.author | Kyung-Mi Lee | - |
dc.date.accessioned | 2015-07-07T19:05:10Z | - |
dc.date.available | 2015-07-07T19:05:10Z | - |
dc.date.created | 2014-12-30 | - |
dc.date.issued | 2014-12-05 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | 2015-OAK-0000030642 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13079 | - |
dc.description.abstract | While stationary organ cells are in continuous contact with neighboring cells, immune cells circulate throughout the body without an apparent requirement for cell-cell contact to persist in vivo. This study challenges current convention by demonstrating, both in vitro and in vivo, that innate immune NK cells can engage in homotypic NK-to-NK cell interactions for optimal survival, activation, and proliferation. Using a specialized cell-laden microwell approach, we discover that NK cells experiencing constant NK-to-NK contact exhibit a synergistic increase in activation status, cell proliferation, and anti-tumor function in response to IL-2 or IL-15. This effect is dependent on 2B4/CD48 ligation and an active cytoskeleton, resulting in amplification of IL-2 receptor signaling, enhanced CD122/CD132 colocalization, CD25 upregulation, and Stat3 activation. Conversely, 'orphan' NK cells demonstrate no such synergy and fail to persist. Therefore, our data uncover the existence of homotypic cell-to-cell communication among mobile innate lymphocytes, which promotes functional synergy within the cytokine-rich microenvironment. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | SCIENTIFIC REPORTS | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | FOREIGN ANTIGEN | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | 2B4 CD244 | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTOR | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | INTERLEUKIN-2 | - |
dc.subject | RECOGNITION | - |
dc.subject | SENSITIVITY | - |
dc.title | Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells | - |
dc.type | Article | - |
dc.contributor.college | 기계공학과 | en_US |
dc.identifier.doi | 10.1038/SREP07157 | - |
dc.author.google | Tae-Jin Kim, Miju Kim, Hye Mi Kim, Seon Ah Lim, Eun-Ok Kim, Kwanghee Kim, Kwang Hoon Song, Jiyoung Kim, Vinay Kumar, Cassian Yee, Junsang Doh, Kyung-Mi Lee | en_US |
dc.relation.volume | 4 | en_US |
dc.relation.startpage | 7157 | en_US |
dc.contributor.id | 10189091 | en_US |
dc.relation.journal | SCIENTIFIC REPORTS | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCIE | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.4, pp.7157 | - |
dc.identifier.wosid | 000346269100001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.startPage | 7157 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | Doh, J | - |
dc.identifier.scopusid | 2-s2.0-84923348290 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 12 | - |
dc.description.scptc | 10 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | FOREIGN ANTIGEN | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | 2B4 CD244 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | INTERLEUKIN-2 | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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