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Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium SCIE SCOPUS

Title
Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium
Authors
Adiyala, Praveen ReddyJang, SeungwookVishwakarma, Niraj K.Hwang, Yoon-HoKim, Dong-Pyo
Date Issued
2020-02
Publisher
ROYAL SOC CHEMISTRY
Abstract
Visible-light-driven continuous-flow decarboxylative annulation was achieved and used along with a microreactor containing immobilized ruthenium catalyst to construct valuable fused imidazole derivatives with high yields under an open atmosphere. Notably, this chemistry included the use of l-proline and alpha-azidochalcone as precursors of an alpha-amino radical and 2H-azirine via photo-induced decarboxylation and denitrogenation, respectively, to give the annulated imidazole derivatives as a result of the formation of two new C-N bonds. Moreover the novel, environmentally benign and efficient continuous-flow protocol was further improved by carrying out the reaction in a polydimethylsiloxane (PDMS) microreactor with immobilized Ru3+ under fluorescent or white LED light, enabling excellent yields (70-94%) at a reaction time (2 min) significantly shorter than that (16 h) of the batch protocol.
URI
https://oasis.postech.ac.kr/handle/2014.oak/107929
DOI
10.1039/c9gc03496j
ISSN
1463-9262
Article Type
Article
Citation
GREEN CHEMISTRY, vol. 22, no. 5, page. 1565 - 1571, 2020-02
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김동표KIM, DONG PYO
Dept. of Chemical Enginrg
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