Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon
SCIE
SCOPUS
- Title
- Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon
- Authors
- Ju, Young-Jun; Lee, Sung-Woo; Kye, Yoon-Chul; Lee, Gil-Woo; Kim, Hee-Ok; Yun, Cheol-Heui; Cho, Jae-Ho
- Date Issued
- 2021-10-18
- Publisher
- Nature Publishing Group
- Abstract
- There is heterogeneity in the response to self-ligands within the naive CD8(+) T cell pool and the consequences of this are unclear. Here the authors show subsets of naive CD8(+) T cells which differ in expression of Ly6C and CD5 and response to viral infection through regulation by type I IFN signalling.
The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8(+) T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5(lo)Ly6C(-), CD5(hi)Ly6C(-), and CD5(hi)Ly6C(+) cells. CD5(hi)Ly6C(+) cells differ from CD5(lo)Ly6C(-) and CD5(hi)Ly6C(-) cells in terms of gene expression profiles and functional properties. Moreover, CD5(hi)Ly6C(+) cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such features of CD5(hi)Ly6C(+) cells are imprinted in a steady-state and type I interferon dependence is observed even for monoclonal CD8(+) T cell populations. These findings demonstrate that self-reactivity controls the functional diversity of naive CD8(+) T cells by co-opting tonic type I interferon signaling.There is heterogeneity in the response to self-ligands within the naive CD8(+) T cell pool and the consequences of this are unclear. Here the authors show subsets of naive CD8(+) T cells which differ in expression of Ly6C and CD5 and response to viral infection through regulation by type I IFN signalling.
The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8(+) T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5(lo)Ly6C(-), CD5(hi)Ly6C(-), and CD5(hi)Ly6C(+) cells. CD5(hi)Ly6C(+) cells differ from CD5(lo)Ly6C(-) and CD5(hi)Ly6C(-) cells in terms of gene expression profiles and functional properties. Moreover, CD5(hi)Ly6C(+) cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such features of CD5(hi)Ly6C(+) cells are imprinted in a steady-state and type I interferon dependence is observed even for monoclonal CD8(+) T cell populations. These findings demonstrate that self-reactivity controls the functional diversity of naive CD8(+) T cells by co-opting tonic type I interferon signaling.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/107591
- DOI
- 10.1038/s41467-021-26351-3
- ISSN
- 2041-1723
- Article Type
- Article
- Citation
- Nature Communications, vol. 12, no. 1, 2021-10-18
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- There are no files associated with this item.
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