DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Young-Jun | - |
dc.contributor.author | Lee, Sung-Woo | - |
dc.contributor.author | Kye, Yoon-Chul | - |
dc.contributor.author | Lee, Gil-Woo | - |
dc.contributor.author | Kim, Hee-Ok | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.contributor.author | Cho, Jae-Ho | - |
dc.date.accessioned | 2021-11-21T07:50:17Z | - |
dc.date.available | 2021-11-21T07:50:17Z | - |
dc.date.created | 2021-11-10 | - |
dc.date.issued | 2021-10-18 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/107591 | - |
dc.description.abstract | There is heterogeneity in the response to self-ligands within the naive CD8(+) T cell pool and the consequences of this are unclear. Here the authors show subsets of naive CD8(+) T cells which differ in expression of Ly6C and CD5 and response to viral infection through regulation by type I IFN signalling. The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8(+) T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5(lo)Ly6C(-), CD5(hi)Ly6C(-), and CD5(hi)Ly6C(+) cells. CD5(hi)Ly6C(+) cells differ from CD5(lo)Ly6C(-) and CD5(hi)Ly6C(-) cells in terms of gene expression profiles and functional properties. Moreover, CD5(hi)Ly6C(+) cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such features of CD5(hi)Ly6C(+) cells are imprinted in a steady-state and type I interferon dependence is observed even for monoclonal CD8(+) T cell populations. These findings demonstrate that self-reactivity controls the functional diversity of naive CD8(+) T cells by co-opting tonic type I interferon signaling.There is heterogeneity in the response to self-ligands within the naive CD8(+) T cell pool and the consequences of this are unclear. Here the authors show subsets of naive CD8(+) T cells which differ in expression of Ly6C and CD5 and response to viral infection through regulation by type I IFN signalling. The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise function and underlying mechanisms are unclear. Here, we demonstrate that naive CD8(+) T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon, resulting in three distinct subsets, CD5(lo)Ly6C(-), CD5(hi)Ly6C(-), and CD5(hi)Ly6C(+) cells. CD5(hi)Ly6C(+) cells differ from CD5(lo)Ly6C(-) and CD5(hi)Ly6C(-) cells in terms of gene expression profiles and functional properties. Moreover, CD5(hi)Ly6C(+) cells demonstrate more extensive antigen-specific expansion upon viral infection, with enhanced differentiation into terminal effector cells and reduced memory cell generation. Such features of CD5(hi)Ly6C(+) cells are imprinted in a steady-state and type I interferon dependence is observed even for monoclonal CD8(+) T cell populations. These findings demonstrate that self-reactivity controls the functional diversity of naive CD8(+) T cells by co-opting tonic type I interferon signaling. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Nature Communications | - |
dc.title | Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-021-26351-3 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature Communications, v.12, no.1 | - |
dc.identifier.wosid | 000708601800008 | - |
dc.citation.number | 1 | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Woo | - |
dc.contributor.affiliatedAuthor | Lee, Gil-Woo | - |
dc.identifier.scopusid | 2-s2.0-85117609575 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | CD5 | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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