Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
SCIE
SCOPUS
- Title
- Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
- Authors
- Champagne, Devin P.; Hatle, Ketki M.; Fortner, Karen A.; D'Alessandro, Angelo; Thornton, Tina M.; Yang, Rui; Torralba, Daniel; Tomas-Cortazar, Julen; Jun, Yong Woong; Ahn, Kyo Han; Hansen, Kirk C.; Haynes, Laura; Anguita, Juan; Rincon, Mercedes
- Date Issued
- 2016-06
- Publisher
- Cell Press
- Abstract
- Mitochondrial respiration is regulated in CD8(+) T cells during the transition from naive to effector and memory cells, but mechanisms controlling this process have not been defined. Here we show that MCJ (methylation-controlled J protein) acted as an endogenous break for mitochondrial respiration in CD8(+) T cells by interfering with the formation of electron transport chain respiratory supercomplexes. Metabolic profiling revealed enhanced mitochondrial metabolism in MCJ-deficient CD8(+) T cells. Increased oxidative phosphorylation and subcellular ATP accumulation caused by MCJ deficiency selectively increased the secretion, but not expression, of interferon-gamma. MCJ also adapted effector CD8(+) T cell metabolism during the contraction phase. Consequently, memory CD8(+) T cells lacking MCJ provided superior protection against influenza virus infection. Thus, MCJ offers a mechanism for fine-tuning CD8(+) T cell mitochondrial metabolism as an alternative to modulating mitochondrial mass, an energetically expensive process. MCJ could be a therapeutic target to enhance CD8(+) T cell responses.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/100295
- DOI
- 10.1016/j.immuni.2016.02.018
- ISSN
- 1074-7613
- Article Type
- Article
- Citation
- Immunity, vol. 44, no. 6, page. 1299 - 1311, 2016-06
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- There are no files associated with this item.
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