DC Field | Value | Language |
---|---|---|
dc.contributor.author | Champagne, Devin P. | - |
dc.contributor.author | Hatle, Ketki M. | - |
dc.contributor.author | Fortner, Karen A. | - |
dc.contributor.author | D'Alessandro, Angelo | - |
dc.contributor.author | Thornton, Tina M. | - |
dc.contributor.author | Yang, Rui | - |
dc.contributor.author | Torralba, Daniel | - |
dc.contributor.author | Tomas-Cortazar, Julen | - |
dc.contributor.author | Jun, Yong Woong | - |
dc.contributor.author | Ahn, Kyo Han | - |
dc.contributor.author | Hansen, Kirk C. | - |
dc.contributor.author | Haynes, Laura | - |
dc.contributor.author | Anguita, Juan | - |
dc.contributor.author | Rincon, Mercedes | - |
dc.date.accessioned | 2019-12-04T15:10:51Z | - |
dc.date.available | 2019-12-04T15:10:51Z | - |
dc.date.created | 2019-02-13 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/100295 | - |
dc.description.abstract | Mitochondrial respiration is regulated in CD8(+) T cells during the transition from naive to effector and memory cells, but mechanisms controlling this process have not been defined. Here we show that MCJ (methylation-controlled J protein) acted as an endogenous break for mitochondrial respiration in CD8(+) T cells by interfering with the formation of electron transport chain respiratory supercomplexes. Metabolic profiling revealed enhanced mitochondrial metabolism in MCJ-deficient CD8(+) T cells. Increased oxidative phosphorylation and subcellular ATP accumulation caused by MCJ deficiency selectively increased the secretion, but not expression, of interferon-gamma. MCJ also adapted effector CD8(+) T cell metabolism during the contraction phase. Consequently, memory CD8(+) T cells lacking MCJ provided superior protection against influenza virus infection. Thus, MCJ offers a mechanism for fine-tuning CD8(+) T cell mitochondrial metabolism as an alternative to modulating mitochondrial mass, an energetically expensive process. MCJ could be a therapeutic target to enhance CD8(+) T cell responses. | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | Immunity | - |
dc.title | Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.immuni.2016.02.018 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Immunity, v.44, no.6, pp.1299 - 1311 | - |
dc.identifier.wosid | 000378341200010 | - |
dc.citation.endPage | 1311 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1299 | - |
dc.citation.title | Immunity | - |
dc.citation.volume | 44 | - |
dc.contributor.affiliatedAuthor | Ahn, Kyo Han | - |
dc.identifier.scopusid | 2-s2.0-84971657476 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LYMPHOCYTE ACTIVATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MCJ/DNAJC15 | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.