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Probing nanomechanical interaction at the interface between biological membrane and potentially toxic chemical

Title
Probing nanomechanical interaction at the interface between biological membrane and potentially toxic chemical
Authors
Lim, ChanoongPark, SoheePark, JinwooKo, JinaLee, Dong WoogHwang, Dong Soo
Date Issued
Jul-2018
Publisher
ELSEVIER SCIENCE BV
Abstract
Various xenobiotics interact with biological membranes, and precise evaluations of the molecular interactions between them are essential to foresee the toxicity and bioavailability of existing or newly synthesized molecules. In this study, surface forces apparatus (SFA) measurement and Langmuir trough based tensiometry are performed to reveal nanomechanical interaction mechanisms between potential toxicants and biological membranes for ex vivo toxicity evaluation. As a toxicant, polyhexamethylene guanidine (PHMG) was selected because PHMG containing humidifier disinfectant and Vodka caused lots of victims in both S. Korea and Russia, respectively, due to the lack of holistic toxicity evaluation of PHMG. Here, we measured strong attraction (Wad similar to 4.2 mJ/m(2)) between PHMG and head group of biological membranes while no detectable adhesion force between the head group and control molecules was measured. Moreover, significant changes in pi-A isotherm of 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) monolayers were measured upon PHMG adsorption. These results indicate PHMG strongly binds to hydrophilic group of lipid membranes and alters the structural and phase behavior of them. More importantly, complementary utilization of SFA and Langmuir trough techniques are found to be useful to predict the potential toxicity of a chemical by evaluating the molecular interaction with biological membranes, the primary protective barrier for living organisms.
URI
http://oasis.postech.ac.kr/handle/2014.oak/95729
ISSN
0304-3894
Article Type
Article
Citation
JOURNAL OF HAZARDOUS MATERIALS, vol. 353, page. 271 - 279, 2018-07
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황동수HWANG, DONG SOO
Div of Environmental Science & Enginrg
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