Inhibition of elongin C promotes longevity and protein homeostasis via HIF‐1 in C. elegans
SCIE
SCOPUS
- Title
- Inhibition of elongin C promotes longevity and protein homeostasis via HIF‐1 in C. elegans
- Authors
- HWANG, WOOSEON; ARTAN, MURAT; MIHWA, SEO; LEE, DONGYEOP; NAM, HONG GIL; LEE, SEUNG JAE
- Date Issued
- 2015-12
- Publisher
- WILEY-BLACKWELL
- Abstract
- The transcription factor hypoxia-inducible factor 1 (HIF-1) is crucial for responses to low oxygen and promotes longevity in Caenorhabditis elegans. We previously performed a genomewide RNA interference screen and identified many genes that act as potential negative regulators of HIF-1. Here, we functionally characterized these genes and found several novel genes that affected lifespan. The worm ortholog of elongin C, elc-1, encodes a subunit of E3 ligase and transcription elongation factor. We found that knockdown of elc-1 prolonged lifespan and delayed paralysis caused by impaired protein homeostasis. We further showed that elc-1 RNA interference increased lifespan and protein homeostasis by upregulating HIF-1. The roles of elongin C and HIF-1 are well conserved in eukaryotes. Thus, our study may provide insights into the aging regulatory pathway consisting of elongin C and HIF-1 in complex metazoans.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94540
- DOI
- 10.1111/acel.12390
- ISSN
- 1474-9718
- Article Type
- Article
- Citation
- AGING CELL, vol. 14, no. 6, page. 995 - 1002, 2015-12
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