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Molecular parts and genetic circuits for metabolic engineering of microorganisms SCIE SCOPUS

Title
Molecular parts and genetic circuits for metabolic engineering of microorganisms
Authors
Kim, Seong GyeongNoh, Myung HyunLim, Hyun GyuJang, SunghoJang, SungyeonKoffas, Mattheos A. G.Jung, Gyoo Yeol
Date Issued
2018-09
Publisher
OXFORD UNIV PRESS
Abstract
Microbial conversion of biomass into value-added biochemicals is a highly sustainable process compared to petroleum-based production. In this regard, microorganisms have been engineered via simple overexpression or deletion of metabolic genes to facilitate the production. However, the producer microorganisms require complex regulatory circuits to maximize productivity and performance. To address this issue, diverse genetic circuits have been developed that allow cells to minimize their metabolic burden, overcome metabolic imbalances and respond to a dynamically changing environment. In this review, we briefly explain the basic strategy for constructing genetic circuits by assembling molecular parts such as input, operation and output modules. Next, we describe recent applications of the circuits in the metabolic engineering of microorganisms to improve biochemical production. Beyond those achievements, genetic circuits will facilitate more innovative approaches to future strain development through mining and engineering new genetic elements and improving the complexity of genetic circuit design.
URI
https://oasis.postech.ac.kr/handle/2014.oak/94501
DOI
10.1093/femsle/fny187
ISSN
0378-1097
Article Type
Article
Citation
FEMS MICROBIOLOGY LETTERS, vol. 365, no. 17, 2018-09
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정규열JUNG, GYOO YEOL
Dept. of Chemical Enginrg
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