Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans
SCIE
SCOPUS
- Title
- Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans
- Authors
- Heehwa G. Son; Keunhee Seo; Mihwa Seo; SANGSOON, PARK; Seokjin Ham; AN, SEON WOO; Eun-Seok Choi; LEE, YUJIN; Haeshim Baek; Eunju Kim; Youngjae Ryu; Chang Man Ha; Ao-Lin Hsu; ROH, TAE YOUNG; JANG, SUNG KEY; LEE, SEUNG JAE
- Date Issued
- 2018-12
- Publisher
- Cold Spring Harbor Laboratory Press
- Abstract
- Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94480
- DOI
- 10.1101/gad.317362.118
- ISSN
- 0890-9369
- Article Type
- Article
- Citation
- Genes and Development, vol. 32, no. 23-24, page. 1562 - 1575, 2018-12
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