Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
SCIE
SCOPUS
- Title
- Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
- Authors
- KIM, TAE KYUNG
- Date Issued
- 2006-02-17
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Abstract
- In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. The genetic program that coordinates this process is poorly understood. We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. In response to increased neuronal activity, calcium influx into neurons induced the activation of the calcium/calmodulin-regulated phosphatase calcineurin, which dephosphorylated and activated MEF2. When activated, MEF2 promoted the transcription of a set of genes, including arc and synGAP, that restrict synapse number. These findings define an activity-dependent transcriptional program that may control synapse number during development.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/94334
- DOI
- 10.1126/science.1122511
- ISSN
- 0036-8075
- Article Type
- Article
- Citation
- SCIENCE, vol. 311, no. 5763, page. 1008 - 1012, 2006-02-17
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- There are no files associated with this item.
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