Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
SCIE
SCOPUS
- Title
- Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
- Authors
- Hwang, AB; Lee, SJ
- Date Issued
- 2011-03
- Publisher
- IMPACT JOURNALS LLC
- Abstract
- A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/9296
- DOI
- 10.18632/aging.100292
- ISSN
- 1945-4589
- Article Type
- Article
- Citation
- AGING-US, vol. 3, no. 3, page. 304 - 310, 2011-03
- Files in This Item:
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