A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery
SCIE
SCOPUS
- Title
- A facile preparation method for nanosized MOFs as a multifunctional material for cellular imaging and drug delivery
- Authors
- Park, K.M.; Kim, H.; Murray, J.; Koo, J.; Kim, K.
- Date Issued
- 2017-06
- Publisher
- TAYLOR & FRANCIS LTD
- Abstract
- Tb-based metal-organic framework nanoparticles (Tb-MOF NPs) with good colloidal stability and stable fluorescence properties in an aqueous solution were prepared by a simple mechanical grinding of Tb-MOF with a biocompatible polymer surfactant (F127). The characteristic fluorescence property of Tb-MOF NPs allowed us to use this nanomaterial as a cell imaging probe. Efficient cellular uptake of Tb-MOF NPs apparently via an energy-dependent endocytosis was observed by confocal laser scanning microscopy. By taking advantage of the porous nature of the Tb-MOF NPs an anticancer drug (doxorubicin) was successfully loaded and delivered to kill cancer cells to demonstrate their usage as a drug delivery vehicle. This simple grinding method afforded a nanosized, multifunctional biomaterial that was used for cell imaging and drug delivery, and it can be extended to other MOFs to widen their applications. ? 2016 Informa UK Limited, trading as Taylor & Francis Group.
- Keywords
- Metal-organic framework; nanoparticles; bioimaging; drug delivery; endocytosis
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/92095
- DOI
- 10.1080/10610278.2016.1266359
- ISSN
- 1061-0278
- Article Type
- Article
- Citation
- SUPRAMOLECULAR CHEMISTRY, vol. 29, no. 6, page. 441 - 445, 2017-06
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