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Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis SCIE SCOPUS
- Title
- Development of a disaggregation-induced emission probe for the detection of RecA inteins from Mycobacterium tuberculosis
- Authors
- Li, Xin; Jiang, Hao; Luo, Zhaofeng; Chang, Young-Tae; Zhang, Liyun
- Date Issued
- 2016-02
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- A fluorescent sensor - InR - with disaggregation-induced emission (DIE) characteristics has been developed for the label free detection of RecA inteins from Mycobacterium tuberculosis. Mechanistic studies demonstrate that InR binds at a hydrophobic pocket of RecA inteins, which is constituted by Gly435, Glu434, Arg405 and Arg 7, resulting in the disaggregation and recovery of its fluorescence.
- Keywords
- AMINO-ACID; PROTEINS; PURIFICATION
- ISSN
- 1359-7345
- Article Type
- Article
- Citation
- CHEMICAL COMMUNICATIONS, vol. 52, no. 58, page. 9086 - 9088, 2016-02
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Related Researcher
- 장영태CHANG, YOUNG TAE
- Dept of Chemistry