PD-1 deficiency protects experimental colitis via alteration of gut microbiota
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- Title
- PD-1 deficiency protects experimental colitis via alteration of gut microbiota
- Authors
- Park, Seong Jeong; Kim, Ji-Hae; Song, Mi-Young; Sung, Young Chul; Lee, Seung-Woo; PARK, YUN JI
- Date Issued
- 2017-11
- Publisher
- 생화학분자생물학회
- Abstract
- Programmed cell death-1 (PD-1) is a coinhibitory molecule and plays a pivotal role in immune regulation. Here, we demonstrate a role for PD-1 in pathogenesis of inflammatory bowel disease (IBD). Wild-type (WT) mice had severe wasting disease during experimentally induced colitis, while mice deficient for PD-1 (PD-1(-/-)) did not develop colon inflammation. Interestingly, PD-1(-/-) mice cohoused with WT mice became susceptible to colitis, suggesting that resistance of PD-1(-/-) mice to colitis is dependent on their gut microbiota. 16S rRNA gene-pyrosequencing analysis showed that PD-1(-/-) mice had altered composition of gut microbiota with significant reduction in Rikenellaceae family. These altered colon bacteria of PD-1(-/-) mice induced less amount of inflammatory mediators from colon epithelial cells, including interleukin (IL)-6, and inflammatory chemokines. Taken together, our study indicates that PD-1 expression is involved in the resistance to experimental colitis through altered bacterial communities of colon.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50855
- DOI
- 10.5483/BMBRep.2017.50.11.165
- ISSN
- 1976-6696
- Article Type
- Article
- Citation
- BMB Reports, vol. 50, no. 11, page. 578 - 583, 2017-11
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