Association between flow skewness and aortic dilatation in patients with aortic stenosis
SCIE
SCOPUS
- Title
- Association between flow skewness and aortic dilatation in patients with aortic stenosis
- Authors
- Ha, Hojin; Koo, Hyun Jung; Lee, June Goo; Kim, Guk Bae; Kweon, Jihoon; Lee, Sang Joon; Kang, Joon Won; Lim, Tae Hwan; Kim, Dae Hee; Song, Jong Min; Kang, Duk Hyun; Song, Jae Kwan; Kim, Young Hak; Kim, Namkug; Yang, Dong Hyun
- Date Issued
- 2017-12
- Publisher
- SPRINGER
- Abstract
- We investigated association between hemodynamic characteristics and aortic dilatation in patients with severe aortic stenosis (AS). Eighty patients with severe AS (mean age, 67.2 +/- 12.5 years) who underwent multi-detector computed tomography and phase-contrast magnetic resonance imaging at the ascending aorta were retrospectively analyzed. Patients with an ascending aorta diameter > 4 cm had a significantly higher forward flow rate at systole (28.5 +/- 6.0 vs. 36.2 +/- 8.6 L min, P < 0.001), and retrograde flow rate at systole (11.3 +/- 4.2 vs. 18.8 +/- 5.8 L min, P < 0.001), fractional reverse ratio (a ratio of retrograde flow rate to forward flow rate; 34.1 +/- 11.9% vs. 43.5 +/- 18.0%, P = 0.014), flow skewness R-skewness (a ratio of sum of forward and retrograde systole flow to net systole flow rate; 2.4 +/- 0.7 vs. 3.2 +/- 1.0, P < 0.001). The presence of bicuspid aortic valve (BAV; odds ratio [OR] 72.01, 95% confidence interval [CI] 10.57-490.46, P < 0.001), Left ventricular mass index (LVMI; OR 1.02 /g/m(2); CI 1.00-1.04, P = 0.043) and R-skewness (OR 5.6 per 1, 95% CI 1.8-17.1, P = 0.001) were associated with aortic dilatation. BAV, LVMI, and increased R-skewness in the ascending aorta are associated with aortic dilatation in patients with AS.
- Keywords
- WALL SHEAR-STRESS; PHASE-CONTRAST MRI; ASCENDING AORTA; BICUSPID AORTOPATHY; VALVE-REPLACEMENT; STENOTIC FLOWS; DILATION; QUANTIFICATION; HEMODYNAMICS; PARAMETERS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50800
- DOI
- 10.1007/s10554-017-1196-x
- ISSN
- 1569-5794
- Article Type
- Article
- Citation
- INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, vol. 33, no. 12, page. 1969 - 1978, 2017-12
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