Well-Defined Biomimicking Brush-Polymer Self-Assemblies Revealing Cholesterol- and Phosphorylcholine-Enriched Surface
SCIE
SCOPUS
- Title
- Well-Defined Biomimicking Brush-Polymer Self-Assemblies Revealing Cholesterol- and Phosphorylcholine-Enriched Surface
- Authors
- Kim, Changsub; Kwon, Kyungho; Lee, Jongchan; Kim, Heesoo; Chae, Keun-Hwa; Ree, Moonhor
- Date Issued
- 2017-09
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We have newly synthesized a series of well-defined brush polyethers bearing cholesterol (Chol) and phosphorylcholine (PC) moieties in various compositions which can mimic cell membrane. They were thermally stable up to at least 230 degrees C and soluble in common solvents, showing good solution processability. Excitingly, they all favorably self assembled, forming multibilayer structures with 2(1) chain conformation; in comparison, the brush polyether bearing only PC-bristles formed orthorhombically packed cylinder (OPC) structure with 12(5) helical chain conformation. Such multibilayer structure formations could be driven by a strong self-assembling ability of the Chol-bristle in extended conformation; the multibilayer structure formation was further promoted by the presence of PC-bristles. The OPC structure formation could be driven by a lateral packing ability of the brush polymer chain in the helical confirmation resulted from the minimization of repulsive interactions in the neighbored zwitterionic PC-bristles. Because of such the self-assembling natures, all brush polymers always revealed Chol- and PC-enriched surface. Overall, all brush polyethers of this study successfully mimicked cell membrane features (Chol- and PC-surface based on self assembling). They are very suitable for uses in the fields required cell membrane surface characteristics.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50655
- DOI
- 10.1021/acs.macromol.7b00805
- ISSN
- 0024-9297
- Article Type
- Article
- Citation
- MACROMOLECULES, vol. 50, no. 17, page. 6489 - 6500, 2017-09
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.