High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles
SCIE
SCOPUS
- Title
- High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles
- Authors
- Peng, Juanjuan; Xu, Wang; Teoh, Chai Lean; Han, Sanyang; Kim, Beomsue; Samanta, Animesh; Er, Jun Cheng; Wang, Lu; Yuan, Lin; Liu, Xiaogang; Chang, Young-Tae
- Date Issued
- 2015-02
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Development of highly sensitive and selective sensing systems of divalent zinc ion (Zn2+) in organisms has been a growing interest in the past decades owing to its pivotal role in cellular metabolism, apoptosis, and neurotransmission. Herein, we report the rational design and synthesis of a Zn2+ fluorescent-based probe by assembling lanthanide-doped upconversion nanoparticles (UCNPs) with chromophores. Specifically, upconversion luminescence (UCL) can be effectively quenched by the chromophores on the surface of nanoparticles via a fluorescence resonant energy transfer (FRET) process and subsequently recovered upon the addition of Zn2+, thus allowing for quantitative monitoring of Zn2+. Importantly, the sensing system enables detection of Zn2+ in real biological samples. We demonstrate that this chromophoreUCNP nanosystem is capable of implementing an efficient in vitro and in vivo detection of Zn2+ in mouse brain slice with Alzheimers disease and zebrafish, respectively.
- Keywords
- CORE-SHELL NANOPARTICLES; UPCONVERTING NANOPARTICLES; PHOTODYNAMIC THERAPY; FLUORESCENT SENSORS; SELECTIVE DETECTION; CYANIDE ANIONS; DRUG-DELIVERY; LUMINESCENT; PROBE; ALZHEIMERS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50386
- DOI
- 10.1021/ja5115248
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 137, no. 6, page. 2336 - 2342, 2015-02
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