Axon-First Neuritogenesis on Vertical Nanowires
SCIE
SCOPUS
- Title
- Axon-First Neuritogenesis on Vertical Nanowires
- Authors
- Kang, Kyungtae; Park, Yi-Seul; Park, Matthew; Jang, Min Jee; Kim, Seong-Min; Lee, Juno; Choi, Ji Yu; Jung, Da Hee; Chang, Young-Tae; Yoon, Myung-Han; Lee, Jin Seok; Nam, Yoonkey; Choi, Insung S.
- Date Issued
- 2016-01
- Publisher
- AMER CHEMICAL SOC
- Abstract
- In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.
- Keywords
- NEURITE OUTGROWTH; HIPPOCAMPAL-NEURONS; ARRAYS; GROWTH; ACCELERATION; CYTOSKELETON; INTERFACES; DYNAMICS; PLATFORM; POLARITY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50371
- DOI
- 10.1021/acs.nanolett.5b04458
- ISSN
- 1530-6984
- Article Type
- Article
- Citation
- NANO LETTERS, vol. 16, no. 1, page. 675 - 680, 2016-01
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.