MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes
SCIE
SCOPUS
- Title
- MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes
- Authors
- Er, Jun Cheng; Tang, Mui Kee; Chia, Chee Geng; Liew, Huimin; Vendrell, Marc; Chang, Young-Tae
- Date Issued
- 2013
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- A novel class of triazole-derivatized BODIPY compounds have been synthesized on solid-phase by employing mild reaction conditions based on the copper-catalyzed azide-alkyne cycloaddition. The resulting BODIPY-triazoles exhibited MegaStokes shifts (up to 160 nm) and remarkable environmentally sensitive quantum yield increments that asserted their potential as turn-on fluorescent sensors. Out of a library of 120 compounds, we identified BDC-9 as a fluorescent chemosensor with high sensitivity and remarkable species-selectivity towards human serum albumin. These results validate MegaStokes BODIPY dyes as new fluorophores for the development of environmentally sensitive fluorescent probes.
- Keywords
- HUMAN-SERUM-ALBUMIN; CRYSTALLOGRAPHIC ANALYSIS REVEALS; QUANTUM-CHEMICAL CALCULATIONS; SPECIES-DEPENDENT BINDING; DRUG-BINDING; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; ENERGY-TRANSFER; FATTY-ACIDS; SPECTRAL PROPERTIES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50326
- DOI
- 10.1039/c3sc22166k
- ISSN
- 2041-6520
- Article Type
- Article
- Citation
- CHEMICAL SCIENCE, vol. 4, no. 5, page. 2168 - 2176, 2013
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