Molecular evolution using intramolecular acyl migration on myo-inositol benzoates with thermodynamic and kinetic selectors
SCIE
SCOPUS
- Title
- Molecular evolution using intramolecular acyl migration on myo-inositol benzoates with thermodynamic and kinetic selectors
- Authors
- Ahn, YH; Chang, Young-Tae
- Date Issued
- 2004-07
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A molecular evolution model was successfully demonstrated by combining the intramolecular acyl migration on inositol tribenzoates and boron selectors. The addition of boric acid to 12 members of DCL (dynamic combinatorial library) induced the dramatic amplification of myo-I(2,4,6)Bz(3) (1) with up to 94% under thermodynamic (see Figure 1c) control while a portion of phenyl boronic acid caused two significant different distributions: under kinetic control, the pre-equilibrium of DCL shifted to induce the exclusive amplification of 1,4,6-tribenzoyl myoinositol (7) with decrease of other members up to 82% from the mixture (see Figure 2b), and changed gradually to form 2,4,6-tribenzoyl myo-inositol (1) with up to 96% under thermodynamic control (Figure 2c).
- Keywords
- DYNAMIC COMBINATORIAL LIBRARIES; LIVING MACROLACTONISATION; MACROCYCLIC DISULFIDES; CONTROLLED CYCLIZATION; AMPLIFICATION; CHEMISTRY; RECEPTOR; LIGAND; ACID; INTERCONVERSION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50168
- DOI
- 10.1002/chem.200400234
- ISSN
- 0947-6539
- Article Type
- Article
- Citation
- CHEMISTRY-A EUROPEAN JOURNAL, vol. 10, no. 14, page. 3543 - 3547, 2004-07
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- There are no files associated with this item.
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