Hyaluronate and Its Derivatives for Customized Biomedical Applications
SCIE
SCOPUS
- Title
- Hyaluronate and Its Derivatives for Customized Biomedical Applications
- Authors
- 김혜민; 정현선; Han, Seul-Gi; 백송은; Hwang, Byung-Woo; Shin, Myeong-Hwan; Oh, Seung-Soo; Hahn, Sei-Kwang
- Date Issued
- 2017-04
- Publisher
- ELSEVIER SCI LTD
- Abstract
- Since hyaluronate (HA) was firstly isolated from the vitreous of bovine eyes in 1934, HA has been widely
investigated for various biomedical applications. As a naturally-occurring polysaccharide, HA has been
used for joint lubrication and ocular treatment in its intact form due to the excellent biocompatibility,
viscoelasticity, biodegradability, and hygroscopic properties. HA can be easily functionalized via the
chemical modification of its carboxyl and hydroxyl groups. Recently, a variety of biological functions of
HA have been explored and a number of customized applications have been investigated taking advantages
of the interaction between HA and biological tissues. HA has been used for drug delivery to
enhance the blood circulation time of drugs with target-specificity to HA receptors in the body. HA has
been also used to prepare tissue engineering hydrogel scaffolds for the spatiotemporal control of
encapsulated cells. In this review, we describe the key biological functions of HA in the body in terms of
its structure, physical properties, biodistribution and interaction with HA receptors. After that, we
describe unique advantages that allow HA to be applied in various biomedical fields. Finally, we report
the conventional and newly emerging applications of HA and its derivatives under commercial development
stages.
- Keywords
- ACID DERMAL FILLERS; TARGETED INTRACELLULAR DELIVERY; TISSUE ENGINEERING SCAFFOLDS; MESENCHYMAL STEM-CELLS; DRY EYE SYNDROME; G-F 20; SODIUM HYALURONATE; MOLECULAR-WEIGHT; DRUG-DELIVERY; SUPRAMOLECULAR HYDROGELS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/41249
- DOI
- 10.1016/j.biomaterials.2017.01.029
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- BIOMATERIALS, vol. 123, page. 155 - 171, 2017-04
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