Two-photon fluorescent probe for hydrogen sulfide based on a red-emitting benzocoumarin dye
SCIE
SCOPUS
- Title
- Two-photon fluorescent probe for hydrogen sulfide based on a red-emitting benzocoumarin dye
- Authors
- SINGHA, SUBHANKAR; RYU, HYE GUN; JUN, YONG WOONG; REO, YE JIN; AHN, KYO HAN
- Date Issued
- 2018-01
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Hydrogen sulfide (H2S) is an endogenous gasotransmitter and plays intriguing biological roles. To study
the biological role of H2S, efficient fluorescent probes are in great demand. For imaging of H2S in deeptissue,
a two-photon probe that emits in the red wavelength region is of choice to avoid the autofluorescence
from intrinsic biomolecules. Here, we disclose such a probe, which, developed based on an acetyl
benzocoumarin fluorophore, can be excited at 900 nm under two-photon excitation and emit in the red
region. The probe shows high reactivity, selectivity, and sensitivity in in vitro assays. Two-photon microscopic
imaging of H2S in HeLa cells aided by the probe demonstrates that it is potentially useful to study
H2S level changes in cells and tissues influenced by external stimuli.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/41195
- DOI
- 10.1016/j.tetlet.2017.11.050
- ISSN
- 0040-4039
- Article Type
- Article
- Citation
- TETRAHEDRON LETTERS, vol. 59, no. 1, page. 49 - 53, 2018-01
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