Open Access System for Information Sharing

Login Library

 

Article
Cited 44 time in webofscience Cited 45 time in scopus
Metadata Downloads

Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer SCIE SCOPUS

Title
Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer
Authors
YUN, EUN JINWu, KaijieGore, CrystalYang, LinFazli, LadanGleave, MartinPong, Rey-ChenXiao, GuanghuaZhang, LinlinTseng, Shu-FenKapur, PayalHe, DalinHsieh, Jer-Tsong
Date Issued
2012-09
Publisher
ENDOCRINE SOC
Abstract
Prostate cancer (PCa) becomes lethal when cancer cells develop into castration-resistant PCa (CRPC). Androgen receptor (AR) gene mutation, altered AR regulation, or overexpression of AR often found in CRPC is believed to become one of the key factors to the lethal phenotype. Here we identify Slug, a member of the Snail family of zinc-finger transcription factors associated with cancer metastasis, as a unique androgen-responsive gene in PCa cells. In addition, the presence of constitutively active AR can induce Slug expression in a ligand-independent manner. Slug overexpression will increase AR protein expression and form a complex with AR. In addition, Slug appears to be a novel coactivator to enhance AR transcriptional activities and AR-mediated cell growth with or without androgen. In vivo, elevated Slug expression provides a growth advantage for PCa cells in androgen-deprived conditions. Most importantly, these observations were validated by several data sets from tissue microarrays. Overall, there is a reciprocal regulation between Slug andARnot only in transcriptional regulation but also in protein bioactivity, and Slug-AR complex plays an important role in accelerating the androgen-independent outgrowth of CRPC. (Molecular Endocrinology 26: 1496-1507, 2012)
URI
https://oasis.postech.ac.kr/handle/2014.oak/40843
DOI
10.1210/me.2011-1360
ISSN
0888-8809
Article Type
Article
Citation
MOLECULAR ENDOCRINOLOGY, vol. 26, no. 9, page. 1496 - 1507, 2012-09
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Views & Downloads

Browse