Analyses of the TCR repertoire in MHC class II-restricted innate CD4+ T cells
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- Title
- Analyses of the TCR repertoire in MHC class II-restricted innate CD4+ T cells
- Authors
- Kang, BH; Min, HS; Lee, YJ; Choi, B; Kim, EJ; Lee, J; Kim, JR; Cho, KH; Kim, TJ; Jung, KC; Park, SH
- Date Issued
- 2015-03
- Publisher
- Nature publishing group
- Abstract
- Analysis of the T-cell receptor (TCR) repertoire of innate CD4(+) T cells selected by major histocompatibility complex (MHC) class II-dependent thymocyte-thymocyte (T-T) interaction (T-T CD4(+) T cells) is essential for predicting the characteristics of the antigens that bind to these T cells and for distinguishing T-T CD4(+) T cells from other types of innate T cells. Using the TCRmini Tg mouse model, we show that the repertoire of TCR alpha chains in T-T CD4(+) T cells was extremely diverse, in contrast to the repertoires previously described for other types of innate T cells. The TCR alpha chain sequences significantly overlapped between T-T CD4(+) T cells and conventional CD4(+) T cells in the thymus and spleen. However, the diversity of the TCR alpha repertoire of T-T CD4(+) T cells seemed to be restricted compared with that of conventional CD4(+) T cells. Interestingly, the frequency of the parental OT-II TCR alpha chains was significantly reduced in the process of T-T interaction. This diverse and shifted repertoire in T-T CD4(+) T cells has biological relevance in terms of defense against diverse pathogens and a possible regulatory role during peripheral T-T interaction.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/39383
- DOI
- 10.1038/EMM.2015.7
- ISSN
- 1226-3613
- Article Type
- Article
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, vol. 47, no. E154, 2015-03
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