Nanoparticle Targeting CD44-Positive Cancer Cells for Site-Specific Drug Delivery in Prostate Cancer Therapy
SCIE
SCOPUS
- Title
- Nanoparticle Targeting CD44-Positive Cancer Cells for Site-Specific Drug Delivery in Prostate Cancer Therapy
- Authors
- YUN, EUN JIN; Huang, Wen-Yin; Lin, Jia-Ni; Hsieh, Jer-Tsong; Chou, Shen-Chieh; Lai, Chih-Ho; Lo, U-Ging; Pong, Rey-Chen; Lin, Jui-Hsiang; Lin, Yu-Hsin
- Date Issued
- 2016-11-16
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Prostate cancer is one of the leading causes of cancer death in adult men and is a multistage disease with therapeutic challenges of local recurrent advanced tumors and distant metastatic disease. CD44 is a multifunctional and multistructural cell surface glycoprotein that is involved in cell-cell interactions, cell proliferation, and cell migration. In the study, we produced negatively charged and biocompatible hyaluronic acid-based nanoparticles as a therapeutic system for targeting CD44-positive cancer cells. Subsequently, we confirmed the delivery of bioactive epigallocatechin-3-gallate and site-specific inhibition of prostate tumor growth. In this study, hyaluronic acid based nanoparticles successfully encapsulated epigallocatechin-3-gallate and were efficiently internalized into cancer cells via CD44 ligand receptor recognition, induced cell cycle arrest at G2/M phase, and inhibited prostate cancer cell growth. Furthermore, in vivo assays indicated that these nanoparticles specifically bind CD44 receptors and increase apoptosis of cancer cells, leading to significant decreases in prostate tumor activity and tumor tissue inflammation.
- Keywords
- GREEN TEA; HYALURONIC-ACID; GASTRIC-CANCER; LIVER-CANCER; STEM-CELLS; CD44; SYSTEM; (-)-EPIGALLOCATECHIN-3-GALLATE; POLYPHENOLS; INHIBITION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/39229
- DOI
- 10.1021/acsami.6b10029
- ISSN
- 1944-8244
- Article Type
- Article
- Citation
- ACS Applied Materials & Interfaces, vol. 8, no. 45, page. 30722 - 30734, 2016-11-16
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.