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Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study SCIE KCI

Title
Energy metabolism and whole-exome sequencing-based analysis of Sasang constitution: a pilot study
Authors
Hyoung Kyu KimHeetak LeeJi Ho SoSeung Hun JeongDae Yun SeoJong Yeol KimSanguk KimJin Han
Date Issued
2017-06
Publisher
한국한의학연구원
Abstract
Background: Traditional Korean Sasang constitutional (SC) medicine categorizes individuals into four constitutional types [Tae-eum (TE), So-eum (SE), Tae-yang (TY), or So-yang (SY)] based on biological and physiological characteristics. As these characteristics are closely related to the bioenergetics of the human body, we assessed the correlation between SC type and energy metabolism features. Methods: Forty healthy, young (22.3 ± 1.4 years) males volunteered to participate in this study. Participants answered an SC questionnaire, and their face shape, voice tone, and body shape were assessed using an SC analysis tool. Thirty-one participants (10 TE, 10 SE, 3 TY, and 8 SY) were selected for further analysis. Collected blood samples were subjected to blood composition analysis, mitochondrial function analysis, and whole-exome sequencing. Results: The SY type showed significantly lower total cholesterol and high-density lipoprotein cholesterol levels than the SE type. Cellular and mitochondrial Adenosine triphosphate (ATP) levels were similar across types. All types showed similar basal mitochondrial oxygen consumption rates, whereas the TE type showed a significantly lower ATP-linked oxygen consumption rate than the other types. Whole-exome sequencing identified several genes variants that were exclusively detected in particular SC types, including 19 for SE, seven for SY, 11 for TE, and six for TY. Conclusion: SC type-specific differences in mitochondrial function and gene mutations were detected in a small group of healthy, young Korean males. These results are expected to greatly improve the accurate screening and utilization of SC medicine.
URI
https://oasis.postech.ac.kr/handle/2014.oak/39075
DOI
10.1016/j.imr.2017.03.002
ISSN
2213-4220
Article Type
Article
Citation
Integrative Medicine Research, vol. 6, no. 2, page. 165 - 178, 2017-06
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김상욱KIM, SANGUK
Dept of Life Sciences
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