Fully chip-embedded automation of a multi-step lab-on-a-chip process using a modularized timer circuit
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- Title
- Fully chip-embedded automation of a multi-step lab-on-a-chip process using a modularized timer circuit
- Authors
- KANG, JUN SU; LEE, DONG HYEON; HEO, YOUNG JIN; CHUNG, WAN KYUN
- Date Issued
- 2017-10
- Publisher
- ROYAL SOCIETY OF CHEMISTRY
- Abstract
- For highly-integrated microfluidic systems, an actuation system is necessary to control the flow; however,
the bulk of actuation devices including pumps or valves has impeded the broad application of integrated
microfluidic systems. Here, we suggest a microfluidic process control method based on built-in microfluidic
circuits. The circuit is composed of a fluidic timer circuit and a pneumatic logic circuit. The fluidic
timer circuit is a serial connection of modularized timer units, which sequentially pass high pressure to the
pneumatic logic circuit. The pneumatic logic circuit is a NOR gate array designed to control the liquidcontrolling
process. By using the timer circuit as a built-in signal generator, multi-step processes could be
done totally inside the microchip without any external controller. The timer circuit uses only two valves per
unit, and the number of process steps can be extended without limitation by adding timer units. As a demonstration,
an automation chip has been designed for a six-step droplet treatment, which entails 1) loading,
2) separation, 3) reagent injection, 4) incubation, 5) clearing and 6) unloading. Each process was successfully
performed for a pre-defined step-time without any external control device.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/38992
- DOI
- 10.1039/c7lc00704c
- ISSN
- 1473-0197
- Article Type
- Article
- Citation
- Lab on a Chip, page. 3891 - 3897, 2017-10
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