A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes
SCIE
SCOPUS
- Title
- A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes
- Authors
- Lee, Do-Hyun; Lee, Woo-Sirl; Sungsu Lim; Yun Kyung Kim; Hoe-Yune Jung; Sanket Das; Lee, Ju-Hyun; Wenjie Luo; Kim, Kyong-Tai; Chung, Sung-Kee
- Date Issued
- 2017-10
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid beta (A beta) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the A beta peptide to inhibit A beta 42 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime. A new strategy to enhance the brain delivery of SI is needed to achieve the efficacy with minimum adverse effects. Herein, we report that a novel guanidine-appended SI derivative AAD-66 resulted in more effective reductions of brain A beta and plaque deposits, gliosis, and behavioral memory deficits in the disease-established 5xFAD mice. Overall, our present study reveals the potential of AAD-66 as a promising therapeutic agent for AD.
- Keywords
- CONTAINING MOLECULAR TRANSPORTERS; DISEASE; RECEPTOR; MYOINOSITOL; PEPTIDE; DESIGN; MODEL; MICE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/38980
- DOI
- 10.1038/s41598-017-14559-7
- ISSN
- 2045-2322
- Article Type
- Article
- Citation
- Scientific Reports, vol. 7, no. 14125, page. 1 - 9, 2017-10
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