Proteomic profiling of Gram-negative bacterial outer membrane vesicles: Current perspectives
- Proteomic profiling of Gram-negative bacterial outer membrane vesicles: Current perspectives
- Lee, Jaewook; Kim, Oh Youn; Gho, Yong Song
- Date Issued
- WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Outer membrane vesicles (OMVs) are extracellular vesicles derived from Gram-negative bacteria. Recent progress in the studies of Gram-negative bacterial extracellular vesicles implies that OMVs may function as intercellular communicasomes in bacteria-bacteria and bacteria-host interactions. Current MS-based high-throughput proteomic analyses of Gram-negative bacterial OMVs have identified thousands of vesicular proteins and provided clues to reveal the biogenesis and pathophysiological functions of Gram-negative bacterial OMVs. The future directions of proteomics of Gram-negative bacterial OMVs may include the isolation strategy of Gram-negative bacterial OMVs to thoroughly exclude nonvesicular contaminants and proteomics of Gram-negative bacterial OMVs derived from diverse conditions as well as body fluids of bacterium-infected hosts. We hope this review will shed light on future research in this emerging field of proteomics of extracellular vesicles derived from Gram-negative bacteria and contribute to the development of OMV-based diagnostic tools and effective vaccines.
- Article Type
- Proteomics Clin Appl, vol. 10, no. 9-10, page. 897 - 909, 2016-10
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