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Proteomic profiling of Gram-negative bacterial outer membrane vesicles: Current perspectives SCIE SCOPUS

Title
Proteomic profiling of Gram-negative bacterial outer membrane vesicles: Current perspectives
Authors
Lee, JaewookKim, Oh YounGho, Yong Song
Date Issued
2016-10
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Abstract
Outer membrane vesicles (OMVs) are extracellular vesicles derived from Gram-negative bacteria. Recent progress in the studies of Gram-negative bacterial extracellular vesicles implies that OMVs may function as intercellular communicasomes in bacteria-bacteria and bacteria-host interactions. Current MS-based high-throughput proteomic analyses of Gram-negative bacterial OMVs have identified thousands of vesicular proteins and provided clues to reveal the biogenesis and pathophysiological functions of Gram-negative bacterial OMVs. The future directions of proteomics of Gram-negative bacterial OMVs may include the isolation strategy of Gram-negative bacterial OMVs to thoroughly exclude nonvesicular contaminants and proteomics of Gram-negative bacterial OMVs derived from diverse conditions as well as body fluids of bacterium-infected hosts. We hope this review will shed light on future research in this emerging field of proteomics of extracellular vesicles derived from Gram-negative bacteria and contribute to the development of OMV-based diagnostic tools and effective vaccines.
URI
https://oasis.postech.ac.kr/handle/2014.oak/37953
DOI
10.1002/PRCA.201600032
ISSN
1862-8346
Article Type
Article
Citation
Proteomics Clin Appl, vol. 10, no. 9-10, page. 897 - 909, 2016-10
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고용송GHO, YONG SONG
Dept of Life Sciences
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