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Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy. SCIE SCOPUS
- Title
- Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy.
- Authors
- Johnson, C. Bryce; Wrangle, John; Mehrotra, Shikhar; Li, Zihai; Paulos, Chrystal M.; Cole, David J.; Surh, CD; Rubinstein, Mark P.
- Date Issued
- 2016-05
- Publisher
- TAYLOR & FRANCIS INC
- Abstract
- IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7R alpha and rely on IL-7 for persistence and antitumor immunity.
- ISSN
- 2162-402X
- Article Type
- Article
- Citation
- ONCOIMMUNOLOGY, vol. 5, no. 5, 2016-05
- Files in This Item:
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Related Researcher
- SURH CHARLES DSURH, CHARLES D
- Div of Integrative Biosci & Biotech