Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
SCIE
SCOPUS
- Title
- Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
- Authors
- Ha, MT; Tran, MH; Ah, KJ; Jo, KJ; Kim, J; Kim, WD; Cheon, WJ; Woo, MH; Ryu, SH; Min, BS
- Date Issued
- 2016-06-15
- Publisher
- ELSEVIER
- Abstract
- Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50 = 0.012 mu M), with IC50 values ranging from 0.09 to 0.92 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37642
- DOI
- 10.1016/J.BMCL.2016.04.066
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 12, page. 2788 - 2794, 2016-06-15
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- There are no files associated with this item.
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